Posts

Hypershell Pro X - MS Review

  I forgot to post an update and what was my experience. In short, since Sept 2024 my gait started being visibly not normal, my mobility slowly got affected until Aug 25 that I had a bad fall. After 1.5 recovering from my accident, ordered the Hypershell Pro X to test (not the carbon, since the weight diff is insignificant fro the extra cost, and really we dont need the extra activities. It will take about 30' to get all on and the BT connection is a bit weird but once done you are set. Set to 25% which is more than enough to walk. 1. its not comfortable to use in the apt/home. really no need to as i dont need a stick also in the house 2. Ι did couple short trip from the apt, going up 10-14 stairs and to the car parking. I felt the support on lifting the legs in the stairs and while walking. Verdict: - As we all know it not made for our condition, and if you gait already affected and not having a good balance, then it isnt for you (or me in my case) - After taking it off...

12y after - Update

Good day to all, I want to share some latest experiences and wanted to hear from you... After 12y Im having a relapse. Mobility became more difficult (walk slower and its visible). 4m ago I had a bad fall (broke left arm, couple ribs and 3-4 stitches on the chin). That scared me and now I prefer to walk with a medical stick support in public. To the point... Since 10y ago I did Ann's Boroch protocol (the 3m strict option) and worked miracle to me (details on my blog, no need to burden ppl here) I thought to start again a be more careful ( last 4-5y I have to admit that I loosened the protocol more than it was suggested, which i believe brought me to my latest condition. All annual MRIs were showing no active lesions in the brain or spine, some seemed were gone and couple new ones again inactive. I have 2 Neuro DRs. My main that did the diagnosis 12y ago within 30' at first appointment. And a specialized Dr at Pasteur hospital in Nice FR. I m taking Tecfidera for lat12y+. (Avone...

Multiple sclerosis and gut microbiota: Lachnospiraceae from the ileum of MS twins trigger MS-like disease in germfree transgenic mice—An unbiased functional study

Hongsup Yoon , Lisa Ann Gerdes https://orcid.org/0000-0002-7053-3924 , Florian Beigel , +9 , and Anneli Peters   Edited by Lawrence Steinman, Stanford University Beckman Center for Molecular and Genetic Medicine, Stanford, CA; received October 16, 2024; accepted February 25, 2025 April 21, 2025     https://www.pnas.org/doi/10.1073/pnas.2419689122

2 treatments to aid remyelination near clinical trials: CVL-1001 inhibits EBP protein, while CVL-2001 blocks the activity of CYP51

 https://multiplesclerosisnewstoday.com/news-posts/2024/03/06/actrims-2024-two-treatments-aid-remyelination-ms-nearing-clinical-trials/   Convelo Therapeutics is developing two experimental oral treatments to promote myelin repair in multiple sclerosis (MS) and both have shown promise in preclinical models. The company is in the final stages of safety studies in large animals. Once those studies are done, it plans to start studies that support regulatory applications to move the treatments toward clinical trials, according to Brad Lang, Convelo’s vice president of research.   https://mtrb.org/the-future-of-stem-cell-therapy-for-ms-multiple-sclerosis-treatment/ Understanding Stem Cell Therapy for MS Types of Stem Cells Used in MS Treatment Recent Advances in Stem Cell Therapy for MS The Potential of Stem Cell Therapy in MS Challenges and Future Directions Conclusion  

A new drug, PIPE-307: New Multiple Sclerosis Drug Regenerates Myelin, Improves Movement

  https://neurosciencenews.com/myelin-movement-ms-neuropharmacology-37518/ Summary: A new drug, PIPE-307, shows promise in reversing multiple sclerosis (MS) damage by promoting myelin regeneration around nerve cells, potentially restoring movement and function. Developed by researchers, this innovative therapy targets a specific receptor, M1R, and has already demonstrated success in animal models. PIPE-307 is currently in Phase II clinical trials, offering hope for a groundbreaking treatment that could stop and even heal the damage caused by MS. This novel approach could transform the future of MS therapy by addressing both symptoms and underlying damage.   New treatment may stop and potentially reverse some nerve damage in MS https://www.medicalnewstoday.com/articles/new-treatment-may-stop-potentially-reverse-nerve-damage-ms#Early-progress-could-give-hope-to-MS-patients  The newly developed drug — PIPE-307 — blocks the M1R receptor, allowing the OPCs to differen...

CNM-Au8: ‘Liquid gold’ could bring new hope to multiple sclerosis patients, study suggests: ‘Profound benefit’

  https://www.foxnews.com/health/liquid-gold-could-bring-new-hope-multiple-sclerosis-patients-study-profound-benefit

They found the "switch" that stops autoimmune diseases "Scientists find switch that stops immune system attacking healthy cells"

https://www.msn.com/en-us/health/other/scientists-find-switch-that-stops-immune-system-attacking-healthy-cells/ar-AA1Aw3a7