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Multiple sclerosis and gut microbiota: Lachnospiraceae from the ileum of MS twins trigger MS-like disease in germfree transgenic mice-An unbiased functional study

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https://pubmed.ncbi.nlm.nih.gov/40258140/?fbclid=IwVERDUATLLfZleHRuA2FlbQIxMABzcnRjBmFwcF9pZAwzNTA2ODU1MzE3MjgAAR7fs4YhIJCdHyWNTp-HhKRW9U-0rNB5p7qOA_62BT1G-PwI-ijAJ5DdMVFtoQ_aem_BHz5O_fZzjEoMof0dqePDg Abstract We developed a two-tiered strategy aiming to identify gut bacteria functionally linked to the development of multiple sclerosis (MS). First, we compared gut microbial profiles in a cohort of 81 monozygotic twins discordant for MS. This approach allowed to minimize confounding effects by genetic and early environmental factors and identified over 50 differently abundant taxa with the majority of increased taxa within the Firmicutes. These included taxa previously described to be associated with MS (Anaerotruncus colihominis and Eisenbergiella tayi), along with newly identified taxa, such as Copromonas and Acutalibacter. Second, we interrogated the intestinal habitat and functional impact of individual taxa on the development of MS-like disease. In an exploratory approach, we enter...
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Kesimpta shot #3 - 06.07.2026

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 ===== Today Monday 6th of July 26, its the 3rd initial shot. Ill take later in the evening as last time and revert tomorrow.  End of next week ill have my first of the 3 requested blood tests. Same once a month for next 3 months. Then head MRI in 6 months
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Kesimpta shot #2 - 29.06.2026

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 ===== Last Monday 29th June got my second shot at 2130 instead of the morning.  It helped by sleeping it over. No need for paracetamol or any headaches, drowsiness etc
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Kesimpta: First Shot 22.06.2026 & How to do it as per assigned nurse at Hopistal Pasteur Nice, FR

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HOW TO DO: As per my first in the hospital I was advised you can do yes at leg , a palm below top and above knee or 5cm away/side of the belly button Rub/clean in circular move you dont need to stab heheh, position vertical, push , when you hear the first click , count to 5, you will hear a second click (green area visible now in full) , at second click count again another 5 then lift the kesimpta pen then clean area injection spot in a cross movements to help spread the liquid done Quick but fully safe =============================  On Monday got my first Kesimpta shot. At the hospital, after showing how, what etc. Kept me couple hours for observation.  No symptoms as described at the pamphlet for about 10-12h Took the shot at 1030am No irritation at the injection area etc. Vey light headache started early afternoon around 1600 but nothing to bother me. (Got 500mg paracetamol) It might be also work related.  Then dinner another 1000mg around 1930 paracetamol and at 22...
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Hypershell Pro X - MS Review

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  I forgot to post an update and what was my experience. In short, since Sept 2024 my gait started being visibly not normal, my mobility slowly got affected until Aug 25 that I had a bad fall. After 1.5 recovering from my accident, ordered the Hypershell Pro X to test (not the carbon, since the weight diff is insignificant fro the extra cost, and really we dont need the extra activities. It will take about 30' to get all on and the BT connection is a bit weird but once done you are set. Set to 25% which is more than enough to walk. 1. its not comfortable to use in the apt/home. really no need to as i dont need a stick also in the house 2. Ι did couple short trip from the apt, going up 10-14 stairs and to the car parking. I felt the support on lifting the legs in the stairs and while walking. Verdict: - As we all know it not made for our condition, and if you gait already affected and not having a good balance, then it isnt for you (or me in my case) - After taking it off...
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12y after - Update

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Good day to all, I want to share some latest experiences and wanted to hear from you... After 12y Im having a relapse. Mobility became more difficult (walk slower and its visible). 4m ago I had a bad fall (broke left arm, couple ribs and 3-4 stitches on the chin). That scared me and now I prefer to walk with a medical stick support in public. To the point... Since 10y ago I did Ann's Boroch protocol (the 3m strict option) and worked miracle to me (details on my blog, no need to burden ppl here) I thought to start again a be more careful ( last 4-5y I have to admit that I loosened the protocol more than it was suggested, which i believe brought me to my latest condition. All annual MRIs were showing no active lesions in the brain or spine, some seemed were gone and couple new ones again inactive. I have 2 Neuro DRs. My main that did the diagnosis 12y ago within 30' at first appointment. And a specialized Dr at Pasteur hospital in Nice FR. I m taking Tecfidera for lat12y+. (Avone...
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Multiple sclerosis and gut microbiota: Lachnospiraceae from the ileum of MS twins trigger MS-like disease in germfree transgenic mice—An unbiased functional study

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Hongsup Yoon , Lisa Ann Gerdes https://orcid.org/0000-0002-7053-3924 , Florian Beigel , +9 , and Anneli Peters   Edited by Lawrence Steinman, Stanford University Beckman Center for Molecular and Genetic Medicine, Stanford, CA; received October 16, 2024; accepted February 25, 2025 April 21, 2025     https://www.pnas.org/doi/10.1073/pnas.2419689122
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