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Multiple sclerosis and gut microbiota: Lachnospiraceae from the ileum of MS twins trigger MS-like disease in germfree transgenic mice-An unbiased functional study

https://pubmed.ncbi.nlm.nih.gov/40258140/?fbclid=IwVERDUATLLfZleHRuA2FlbQIxMABzcnRjBmFwcF9pZAwzNTA2ODU1MzE3MjgAAR7fs4YhIJCdHyWNTp-HhKRW9U-0rNB5p7qOA_62BT1G-PwI-ijAJ5DdMVFtoQ_aem_BHz5O_fZzjEoMof0dqePDg Abstract We developed a two-tiered strategy aiming to identify gut bacteria functionally linked to the development of multiple sclerosis (MS). First, we compared gut microbial profiles in a cohort of 81 monozygotic twins discordant for MS. This approach allowed to minimize confounding effects by genetic and early environmental factors and identified over 50 differently abundant taxa with the majority of increased taxa within the Firmicutes. These included taxa previously described to be associated with MS (Anaerotruncus colihominis and Eisenbergiella tayi), along with newly identified taxa, such as Copromonas and Acutalibacter. Second, we interrogated the intestinal habitat and functional impact of individual taxa on the development of MS-like disease. In an exploratory approach, we enter...

Kesimpta shot #3 - 06.07.2026

 ===== Today Monday 6th of July 26, its the 3rd initial shot. Ill take later in the evening as last time and revert tomorrow.  End of next week ill have my first of the 3 requested blood tests. Same once a month for next 3 months. Then head MRI in 6 months

Kesimpta shot #2 - 29.06.2026

 ===== Last Monday 29th June got my second shot at 2130 instead of the morning.  It helped by sleeping it over. No need for paracetamol or any headaches, drowsiness etc

Kesimpta: First Shot 22.06.2026 & How to do it as per assigned nurse at Hopistal Pasteur Nice, FR

HOW TO DO: As per my first in the hospital I was advised you can do yes at leg , a palm below top and above knee or 5cm away/side of the belly button Rub/clean in circular move you dont need to stab heheh, position vertical, push , when you hear the first click , count to 5, you will hear a second click (green area visible now in full) , at second click count again another 5 then lift the kesimpta pen then clean area injection spot in a cross movements to help spread the liquid done Quick but fully safe =============================  On Monday got my first Kesimpta shot. At the hospital, after showing how, what etc. Kept me couple hours for observation.  No symptoms as described at the pamphlet for about 10-12h Took the shot at 1030am No irritation at the injection area etc. Vey light headache started early afternoon around 1600 but nothing to bother me. (Got 500mg paracetamol) It might be also work related.  Then dinner another 1000mg around 1930 paracetamol and at 22...

Hypershell Pro X - MS Review

  I forgot to post an update and what was my experience. In short, since Sept 2024 my gait started being visibly not normal, my mobility slowly got affected until Aug 25 that I had a bad fall. After 1.5 recovering from my accident, ordered the Hypershell Pro X to test (not the carbon, since the weight diff is insignificant fro the extra cost, and really we dont need the extra activities. It will take about 30' to get all on and the BT connection is a bit weird but once done you are set. Set to 25% which is more than enough to walk. 1. its not comfortable to use in the apt/home. really no need to as i dont need a stick also in the house 2. Ι did couple short trip from the apt, going up 10-14 stairs and to the car parking. I felt the support on lifting the legs in the stairs and while walking. Verdict: - As we all know it not made for our condition, and if you gait already affected and not having a good balance, then it isnt for you (or me in my case) - After taking it off...

12y after - Update

Good day to all, I want to share some latest experiences and wanted to hear from you... After 12y Im having a relapse. Mobility became more difficult (walk slower and its visible). 4m ago I had a bad fall (broke left arm, couple ribs and 3-4 stitches on the chin). That scared me and now I prefer to walk with a medical stick support in public. To the point... Since 10y ago I did Ann's Boroch protocol (the 3m strict option) and worked miracle to me (details on my blog, no need to burden ppl here) I thought to start again a be more careful ( last 4-5y I have to admit that I loosened the protocol more than it was suggested, which i believe brought me to my latest condition. All annual MRIs were showing no active lesions in the brain or spine, some seemed were gone and couple new ones again inactive. I have 2 Neuro DRs. My main that did the diagnosis 12y ago within 30' at first appointment. And a specialized Dr at Pasteur hospital in Nice FR. I m taking Tecfidera for lat12y+. (Avone...

Multiple sclerosis and gut microbiota: Lachnospiraceae from the ileum of MS twins trigger MS-like disease in germfree transgenic mice—An unbiased functional study

Hongsup Yoon , Lisa Ann Gerdes https://orcid.org/0000-0002-7053-3924 , Florian Beigel , +9 , and Anneli Peters   Edited by Lawrence Steinman, Stanford University Beckman Center for Molecular and Genetic Medicine, Stanford, CA; received October 16, 2024; accepted February 25, 2025 April 21, 2025     https://www.pnas.org/doi/10.1073/pnas.2419689122

2 treatments to aid remyelination near clinical trials: CVL-1001 inhibits EBP protein, while CVL-2001 blocks the activity of CYP51

 https://multiplesclerosisnewstoday.com/news-posts/2024/03/06/actrims-2024-two-treatments-aid-remyelination-ms-nearing-clinical-trials/   Convelo Therapeutics is developing two experimental oral treatments to promote myelin repair in multiple sclerosis (MS) and both have shown promise in preclinical models. The company is in the final stages of safety studies in large animals. Once those studies are done, it plans to start studies that support regulatory applications to move the treatments toward clinical trials, according to Brad Lang, Convelo’s vice president of research.   https://mtrb.org/the-future-of-stem-cell-therapy-for-ms-multiple-sclerosis-treatment/ Understanding Stem Cell Therapy for MS Types of Stem Cells Used in MS Treatment Recent Advances in Stem Cell Therapy for MS The Potential of Stem Cell Therapy in MS Challenges and Future Directions Conclusion  

A new drug, PIPE-307: New Multiple Sclerosis Drug Regenerates Myelin, Improves Movement

  https://neurosciencenews.com/myelin-movement-ms-neuropharmacology-37518/ Summary: A new drug, PIPE-307, shows promise in reversing multiple sclerosis (MS) damage by promoting myelin regeneration around nerve cells, potentially restoring movement and function. Developed by researchers, this innovative therapy targets a specific receptor, M1R, and has already demonstrated success in animal models. PIPE-307 is currently in Phase II clinical trials, offering hope for a groundbreaking treatment that could stop and even heal the damage caused by MS. This novel approach could transform the future of MS therapy by addressing both symptoms and underlying damage.   New treatment may stop and potentially reverse some nerve damage in MS https://www.medicalnewstoday.com/articles/new-treatment-may-stop-potentially-reverse-nerve-damage-ms#Early-progress-could-give-hope-to-MS-patients  The newly developed drug — PIPE-307 — blocks the M1R receptor, allowing the OPCs to differen...

CNM-Au8: ‘Liquid gold’ could bring new hope to multiple sclerosis patients, study suggests: ‘Profound benefit’

  https://www.foxnews.com/health/liquid-gold-could-bring-new-hope-multiple-sclerosis-patients-study-profound-benefit

They found the "switch" that stops autoimmune diseases "Scientists find switch that stops immune system attacking healthy cells"

https://www.msn.com/en-us/health/other/scientists-find-switch-that-stops-immune-system-attacking-healthy-cells/ar-AA1Aw3a7

Dr. Dimitris Karousis Info

Dr Karousis brief info or https://esni.isniweb.org/karussis-dimitrios/ or https://brainlabs.org.il/about-us/scientists/prof-dimitrios-karussis/ Papers by Dimitrios Karussis YT 3rd party presentation in Hellenic https://youtu.be/uUbCx01McAM

Over-the-counter antihistamine repairs nerve damage caused by MS

  https://newatlas.com/medical/antihistamine-reverses-ms-nerve-damage/ A new study has found direct evidence that an over-the-counter antihistamine can repair the protective nerve sheath that’s damaged in people with multiple sclerosis. ... Now, researchers from the University of California San Francisco have identified an over-the-counter antihistamine called clemastine that can reverse damage to the myelin sheath and, what’s more, they’ve identified a biomarker that can measure the drug’s effectiveness. Read the article for more info...  Hope never dies... Other links I found: -  https://multiplesclerosisnewstoday.com/2018/06/08/ms-experience-allergy-medication-clemastine/ -  https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(17)32346-2/fulltext?elsca1=tlxpr

Multiple sclerosis: the link with earlier infection just got stronger – new study

Republished from... Multiple sclerosis: the link with earlier infection just got stronger – new study October 11, 2021 7.06pm BST   Scott Montgomery ,  UCL For most of the time since the  first description  of multiple sclerosis (MS) in 1868, the causes of this disabling disease have remained uncertain. Genes have been identified as important, which is why having other family members with MS is associated with a greater risk of developing the disease. A  recent study  my colleagues and I conducted found that several types of infection during the teenage years are associated with MS after age 20. Our study didn’t investigate whether people who are more likely to have genetic risks for MS were also more likely to have worse infections. This might explain why people with MS also have more infections that need hospital treatment. If this were the explanation, the infection would not be a risk factor triggering MS, it would only identify those more likely t...

Vegan Diet = Fat & weight loss + gut health...

Researchers may have figured out why vegan diets lead to weight and fat loss even if dieters don’t cut calories... https://www.insider.com/vegan-diet-leads-to-weight-fat-loss-improves-gut-bacteria-2019-9

8 years LATER... (Updated 12.10.2021)

I hope you are all well and feel better! I have reversed MS at 90% to this day and all thank to dear God rest her soul Ann Boroch! She asked me if she could post my story on her Facebook and I said of course so you might see some info there too! I am a real person for those you know me also in person. Worked hard all my life and stressed a lot too due to that. Long hours, stress etc. 8y ago I got diagnosed with MS. My first appointment with my neurologist to this day Dr Adlerfligel in Monaco. Quick recap for those dont know my story... - I got my first attack (which I didn't know) in March 2013.  Lasted 7d and symptoms disappeared. I got numbness from my knees and down. - I got my second bigger attack in May 2013 which lasted 14+ days and wouldn't go away. I was numb on my complete right side and tingling on my hands and feet. - I started with AVONEX ® (interferon beta-1a) in Sept 2013. After 2y my condition deteriorated and ended up walking with a cane s...

Spanakorizo (Spinach with rice)

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This is a typical Hellenic healthy dish. Add virgin olive oil and fresh lemon to your plate and enjoy.  After 3rd month if you want to spoil your self add a small piece of goat Feta cheese on the side!  Tip: As dairy ptoducts are not permitted  Feta goat cheese is a small treat but not something to be used to. Only goat products allowed in the plan and in very small and moderate quantities.  Ingredients 1/3 cup olive oil2 onions, chopped 2 pounds fresh spinach, rinsed and stemmed1 (8 ounce) can tomato sauce (optional version 2) 2 cups water 1 teaspoon dried dill weed 1 teaspoon dried parsleysalt and pepper to taste 1/2 cup uncooked white rice Directions Heat olive oil in a large skillet over medium-high heat. Saute onions in the oil until soft and translucent. Add spinach, and cook stirring for a few minutes, then pour in the tomato sauce and water. Bring to a boil, and season with parsley, dill, salt and pepper. Stir in rice, reduce heat t...

Dessert: Strawberry Shortcake Free of Glutten - White Sugar

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http://www.huffingtonpost.com/danette-may/gluten-free-strawberry-shortcake_b_10052642.html

Desserts Ideas:

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Banana cake (Vegan) Vegan cookies

Huntington’s breakthrough may stop disease

Huntington’s breakthrough may stop disease Link Here